From:	ees.fct.0.16d914.455a1be3@eesmail.elsevier.com on behalf of Food and 
Chemical Toxicology [fct@elsevier.com]
Sent:	29 January 2012 10:49
To:	rankovic@kg.ac.rs
Subject:	Invitation to review FCT-D-11-02141

Ms. Ref. No.:  FCT-D-11-02141
Title: Evaluation of Antiarthritic Activity of Isoeugenol in Adjuvant induced 
Arthritis in Murine Model Food and Chemical Toxicology

Dear Dr Rankovic,

On Jan 26, 2012, I sent you the abstract below, which has been submitted for 
consideration for publication in Food and Chemical Toxicology.  I would be 
most grateful if you could find the time to read the paper and comment on its 
suitability for publication.

Please let me know whether you are able to carry out the review by logging 
onto the system at: http://ees.elsevier.com/fct/ and accepting or declining 
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Thank you very much for your assistance.

Yours sincerely,

Prof. Jose L. Domingo
Editor
Food and Chemical Toxicology

ABSTRACT:
In the present study, we investigated the effect of isoeugenol on 
experimentally induced adjuvant arthritis in rats. Induction of arthritis in 
adjuvant exposed rats was confirmed by appearance of several physical symptoms 
such as redness, swelling and stiffness of paws, radiographic analysis 
revealing joint damage, soft tissue swelling of the footpad, histopathologic 
changes and expression of proinflammatory enzymes and mediators in the joint 
tissue. Treatment of rats with isoeugenol, however, conferred a significant 
protection against almost all the investigated parameters. Isoeugenol 
significantly and dose dependently attenuated arthritic index, paw 
circumference, joint stiffness and the levels of proinflammatory mediators. 
Exposure to isoeugenol inhibited the release of nitric oxide and 
proinflammatory cytokines the including PGE2 and TNF-alpha from 
lipopolysaccharide primed macrophages. Isoeugenol also showed a significant 
analgesic activity in acetic acid-induced writhing model. Further, unlike most 
antiarthritic drugs, isoeugenol had no damaging effect on gastric mucosa 
making it a favorable antiarthritic drug. Thus, the results obtained in the 
present study indicate isoeugenol to possess a promising antiarthritic 
activity and further advocate the efficacy of natural products as 
antiarthritic therapeutics.

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