From:	ees.fct.0.16c88a.720a8ae6@eesmail.elsevier.com on behalf of Food and 
Chemical Toxicology [fct@elsevier.com]
Sent:	26 January 2012 12:15
To:	rankovic@kg.ac.rs
Subject:	Reviewer Invitation for FCT-D-11-02141

Ms. Ref. No.:  FCT-D-11-02141
Title: Evaluation of Antiarthritic Activity of Isoeugenol in Adjuvant induced 
Arthritis in Murine Model Food and Chemical Toxicology

Dear Dr Rankovic,

You are invited to review the above-mentioned manuscript that has been 
submitted for publication in Food and Chemical Toxicology.

The manuscript abstract is attached below.  

If you are willing to review this manuscript, please click on the link below:
http://ees.elsevier.com/fct/l.asp?i=54931&l=HOS4JDDM

If you are unable, please click on the link below. We would appreciate 
receiving suggestions for alternative reviewers:
http://ees.elsevier.com/fct/l.asp?i=54930&l=VODPUQAK

Alternatively, you may register your response by accessing the Elsevier 
Editorial System for Food and Chemical Toxicology as a REVIEWER using the 
login credentials below:

http://ees.elsevier.com/fct/
Your username is: BRankovic-335
If you need to retrieve password details, please go to: 
http://ees.elsevier.com/fct/automail_query.asp

If you accept this invitation, I would be very grateful if you would return 
your review within 15 days.

You may submit your comments online at the above URL. There you will find 
spaces for confidential comments to the editor, comments for the author and a 
report form to be completed.

To assist you in the reviewing process, I am delighted to offer you full 
access to Scopus* for 30 days. With Scopus you can search for related 
articles, references and papers by the same author. You may also use Scopus 
for your own purposes at any time during the 30-day period. If you already use 
Scopus at your institute, having this 30 day full access means that you will 
also be able to access Scopus from home. Access instructions will follow once 
you have accepted this invitation to review

*Scopus is the world's largest abstract and citation database of research 
information and quality internet sources.

With kind regards,

Jose L. Domingo, PhD
Editor
Food and Chemical Toxicology

Reviewer Guidelines are now available to help you with your review: 
http://www.elsevier.com/wps/find/reviewershome.reviewers/reviewersguidelines 

ABSTRACT:
In the present study, we investigated the effect of isoeugenol on 
experimentally induced adjuvant arthritis in rats. Induction of arthritis in 
adjuvant exposed rats was confirmed by appearance of several physical symptoms 
such as redness, swelling and stiffness of paws, radiographic analysis 
revealing joint damage, soft tissue swelling of the footpad, histopathologic 
changes and expression of proinflammatory enzymes and mediators in the joint 
tissue. Treatment of rats with isoeugenol, however, conferred a significant 
protection against almost all the investigated parameters. Isoeugenol 
significantly and dose dependently attenuated arthritic index, paw 
circumference, joint stiffness and the levels of proinflammatory mediators. 
Exposure to isoeugenol inhibited the release of nitric oxide and 
proinflammatory cytokines the including PGE2 and TNF-alpha from 
lipopolysaccharide primed macrophages. Isoeugenol also showed a significant 
analgesic activity in acetic acid-induced writhing model. Further, unlike most 
antiarthritic drugs, isoeugenol had no damaging effect on gastric mucosa 
making it a favorable antiarthritic drug. Thus, the results obtained in the 
present study indicate isoeugenol to possess a promising antiarthritic 
activity and further advocate the efficacy of natural products as 
antiarthritic therapeutics.


******************************************
For further assistance, please visit our customer support site at 
http://support.elsevier.com Here you can search for solutions on a range of 
topics, find answers to frequently asked questions and learn more about EES 
via interactive tutorials. You will also find our 24/7 support contact details 
should you need any further assistance from one of our customer support 
representatives.
