From:	em.chembiodiv.5fac45b.4c4fb7.14702403@editorialmanager.com on behalf 
of Kathrin Andrea Brun [em@editorialmanager.com]
Sent:	Tuesday, July 05, 2016 3:53 PM
To:	Branislav R. Rankovic
Subject:	Request To Referee Manuscript cbdv.201600239 from Dr. Sergio Enrico 
Favero Longo et al.

Dear Prof. Rankovic,

The Full Paper "Secondary metabolite variability and medullary elemental 
composition in populations of the lichen Xanthoparmelia" by Dr. Sergio Enrico 
Favero Longo (Manuscript Number: cbdv.201600239) has been submitted to 
Chemistry and Biodiversity.
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Dr. Kathrin Andrea Brun  
Associate Editor 
Chemistry and Biodiversity

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ABSTRACT

Lichen secondary metabolites (LSMs) are regarded with interest for potentially 
valuable biological properties, but knowledge of their patterns of occurrence 
is still fragmentary. In particular, the potential relationship between 
environmental factors and chemical variability between/within lichen taxa has 
been only partially explored. Here we evaluate the chemical variability in the 
green-yellow Xanthoparmelia complex, at the local scale in two sites of 
Western Italian Alps, and we assess relationships between the LSMs and 
elemental contents of thalli. Qualitative and quantitative analyses were 
performed by HPLC-DAD-ESI-MS2 and UPLC-HDR-DAD, respectively, and revealed the 
occurrence of 18 LSMs, including four unidentified compounds. Chemical 
partition allowed distinguishing six chemical groups, only partially 
overlapping with ITS haplotype groups. In the haplotype group encompassing 
specimens with the depsidone salazinic acid (5) and/or an unidentified 
metabolite with [M-H]-
373 m/z (11) as main compounds, the concentration of the former was positively 
correlated to mineral macronutrients and negatively to metal micronutrients 
derived from the bedrock, as quantified by XRF-spectroscopy. The latter 
metabolite showed an opposite trend. Our results indicate the richness and 
complexity of lichen local populations as sources of natural products and 
prompt further research on the synthesis of LSMs in controlled conditions of 
metal availability.


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